内洋地黄素与脑血管疾病_药学论文

内洋地黄素与脑血管疾病

简介： 原文内洋地黄素又称内源性地高辛样物质(endogenous digitalis-like substance, EDLS)、内源性地高辛样因子(endogenous digitalis-like factor, EDLF)或内源性哇巴因样物质(endogenous ouabain-like substance, EOLS)，是体内产生和分泌的一种...

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原文

内洋地黄素又称内源性地高辛样物质(endogenous digitalis-like substance, EDLS)、内源性地高辛样因子(endogenous digitalis-like factor, EDLF)或内源性哇巴因样物质(endogenous ouabain-like substance, EOLS)，是体内产生和分泌的一种具有洋地黄样生物活性的物质，主要分布于下丘脑和肾上腺，具有利尿利钠、缩血管和强心作用。研究证明，细胞膜Na+,K+-ATP酶的α-亚基是洋地黄的受体，内洋地黄素是洋地黄受体的内源性介质，能显著抑制Na+,K+-ATP酶活性。近年来的研究发现，患有脑血管疾病的人和动物，体内内洋地黄素的水平发生改变，其含变化与脑血管痉挛和意识改变程度相关。本文对内洋地黄素的生理作用及其与脑血管病的关系作一介绍，并探讨其拮抗剂可能在脑血管疾病中的应用前景。
1 内洋地黄素的分泌与生物学活性
内洋地黄素在体内分布广泛，存在于脑、心、肝、肺、肾、肌肉、肾上腺和胎盘等多种组织，以及脑脊液、血浆和尿液中。大鼠下丘脑含量最高，约为(101±13) pg/mg，心脏含量为(52±7) fmol/pg，豚鼠心脏含量最丰富，红细胞内也含有。

1 内洋地黄素的分泌与生物学活性
2 内洋地黄素与脑血管病
3 洋地黄抗体在脑血管病治疗中的可能作用

参考资料

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内洋地黄素与脑血管疾病

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